Year : 2009  |  Volume : 51  |  Issue : 4  |  Page : 276--279

Apoptosis in subicular neurons: A comparison between suicide and Addison俟Q製 disease


K Printha1, SR Hulathduwa2, K Samarasinghe3, YH Suh4, K. R. D De Silva1 
1 Genetic Diagnostic and Research Laboratory, Department of Anatomy, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
2 Department of Forensic Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
3 Department of Pathology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
4 Department of Pharmacology, College of Medicine, Seoul National University, Seoul, South Korea

Correspondence Address:
K. R. D De Silva
Department of Anatomy, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka

Background: Stress and depression shows possible links to neuronal death in hippocampus. Subiculum plays a prominent role in limbic stress integration and direct effect of corticosteroids on subicular neurons needs to be defined to assess its subsequent impact on hippocampal plasticity. Aim: This study was intended to assess apoptosis in subicular neurons of a young depressed suicide victim, where presumably stress induced excess of corticosteroids and a case of young Addison俟Q製 disease with low level of corticosteroids. Materials and Method: Both bilateral adrenal glands (Addison俟Q製) and subiculum (both cases) were initially stained with hematoxylin and eosin; subicular neurons of both cases were examined for the degree of apoptosis using 俟Q翠popTag Kit俟Q. Apoptotic cell counts were expressed as average number of labeled cells/mm 2 and the results were analysed statistically using a non-parametric Mann-Whitney U test. Result: Apoptotic neurons were detected in the subicular region of both suicide and Addison victims, and it is statistically significant in both right and left between the cases (P < 0.05). In suicide victim, the neuronal apoptosis is considerably significant between the two hemispheres (P < 0.05), in contrast to Addison disease where the number of neuronal cell death between right and left was statistically insignificant (P > 0.05). Conclusion: The present study confirms the vulnerability of the subicular neurons to apoptosis, possibly due to corticosteroids in both ends of spectrum.


How to cite this article:
Printha K, Hulathduwa S R, Samarasinghe K, Suh Y H, De Silva K. Apoptosis in subicular neurons: A comparison between suicide and Addison's disease.Indian J Psychiatry 2009;51:276-279


How to cite this URL:
Printha K, Hulathduwa S R, Samarasinghe K, Suh Y H, De Silva K. Apoptosis in subicular neurons: A comparison between suicide and Addison's disease. Indian J Psychiatry [serial online] 2009 [cited 2021 May 7 ];51:276-279
Available from: https://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2009;volume=51;issue=4;spage=276;epage=279;aulast=Printha;type=0