Year : 1999  |  Volume : 41  |  Issue : 4  |  Page : 325--328

A Comparative Efficacy Study of Centbutindole and Haloperidol in Schizophrenia


Harjeet Singh1, JS Srivastava2, Charu Raghuvanshi3, PK Dalal3, OP Asthana4 
1 Professor, Department of Psychiatry, K.G.'s Medical College, Lucknow, India
2 Scientist, Division of Cinical & Experimental Medicine, C.D.R.I., Lucknow, India
3 Professor, Department of of Psychiatry, KG's Medical College, Lucknow, India
4 Head, Division of Cinical & Experimental Medicine, C.D.R.I., Lucknow, India

Correspondence Address:
Harjeet Singh
Professor, Department of Psychiatry, K.G.SQs Medical College, Lucknow
India

A double blind study was undertaken to compare the efficacy between centbutindole and haloperidol. A total of 44 patients suffering from schizophrenia diagnosed in accordance to ICD-10 criteria were included. They were randomly assigned into two groups receiving centbutindole (4.5 mg) or haloperidol (15 mg) in two divided doses per day for six weeks. Each patient was evaluated on Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Scale (CGI-S) and UKU side effect scale every week. Five patients (1 patient in centbutindole group, 4 patients in haloperidol group) dropped out due to various reasons. A total of 39 patients (21 patients in centbutindole group and 18 patients in haloperidol group) completed the study. The results revealed an early onset of therapeutic effect with centbutindole for both positive and negative symptoms. However, the efficacy was comparable between centibutindole and haloperidol from 3rd week onwards.


How to cite this article:
Singh H, Srivastava J S, Raghuvanshi C, Dalal P K, Asthana O P. A Comparative Efficacy Study of Centbutindole and Haloperidol in Schizophrenia.Indian J Psychiatry 1999;41:325-328


How to cite this URL:
Singh H, Srivastava J S, Raghuvanshi C, Dalal P K, Asthana O P. A Comparative Efficacy Study of Centbutindole and Haloperidol in Schizophrenia. Indian J Psychiatry [serial online] 1999 [cited 2021 May 6 ];41:325-328
Available from: https://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=1999;volume=41;issue=4;spage=325;epage=328;aulast=Singh;type=0