| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 62
| Issue : 6 | Page : 659-663 |
Is serum complement C1q related to major depressive disorder?
Jing Yang1, Ruibo Li1, Yuanhong Shi2, Siyu Jiang1, Jing Liu1
1 Department of Clinical Psychology, Dalian Medical University, Dalian; Department of Clinical Psychology, SuBei Hospital, Affiliated Hospitals of Yangzhou University, Yangzhou, China
2 Department of Clinical Psychology, SuBei Hospital, Affiliated Hospitals of Yangzhou University, Yangzhou, China
Correspondence Address:
Dr. Yuanhong Shi
Department of Clinical Psychology, SuBei Hospital, Affiliated Hospitals of Yangzhou University, 98, Nan-Tong-Xi-Lu Yangzhou, Jiangsu Province, 225000
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/psychiatry.IndianJPsychiatry_394_19
Background: Major depressive disorder (MDD) has a high global incidence. While the pathogenesis of depression remains unknown, accumulating evidence has implicated inflammatory changes.
Aim: The aim of the study is to compare the serum complement C1q levels in patients with MDD and healthy controls.
Setting and Design: The design was a case–control study.
Materials and Methods: Blood samples were collected from the patients with MDD and healthy controls to assess the serum C1q levels using an immunotransmission turbidimetric method.
Statistical Analysis: Differences in complement C1q levels between patients with MDD and the controls, as well as between sexes among patients with MDD and the controls, were assessed using Mann–Whitney U-test. Spearman correlations were obtained between complement C1q levels and age.
Results: In total, 1016 participants (508 MDD and 508 controls) were recruited. Differences in the sex ratio (male/female among controls, 181/327; and MDD, 178/330) and age (controls, 47.0 ± 14.9 years; MDD, 46.5 ± 16.5 years) were not significant. The C1q level in the patients with MDD was significantly higher than that in the healthy controls (P < 0.05). In the MDD group, C1q level correlated significantly with age.
Conclusion: Elevation of the serum complement C1q levels in MDD may support the use of C1q as a potential biomarker for diagnosing depression, but further research is needed.
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