Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 2020  |  Volume : 62  |  Issue : 1  |  Page : 97-99

Neuropsychiatric manifestations of methyl iodide toxicity

1 Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India
2 Department of Medicine, Government Medical College and Hospital, Chandigarh, India
3 Department of Radiology, Government Medical College and Hospital, Chandigarh, India

Correspondence Address:
Dr. Ajeet Sidana
Department of Psychiatry, Government Medical College and Hospital, Sector - 32, Chandigarh - 160 030
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/psychiatry.IndianJPsychiatry_638_19

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Methyl iodide is an industrial chemical used in methylation for pharmaceutical intermediates. Its toxicity is a rare industrial hazard. Its toxicity is reported with both acute sudden exposure and gradual exposure. The authors report a case of methyl iodide toxicity occurring in a 47 year-old male with sudden exposure to this chemical. He presented with neuropsychiatric symptoms primarily slurring of speech, ataxia followed by delusion and hallucinations which resolved within 2 weeks with parenteral thiamine and an antipsychotic. Symptoms reappeared after a re-exposure, this time with more prominent psychiatric symptoms which were late to resolve (4 weeks) with similar treatment. Neuroimaging revealed hyperintensities in posterior regions of the brain which resolved after 4 weeks. The patient had prominent neurocognitive deficits which were persistent. The case highlights the rare chemical toxicity with neuropsychiatric manifestations with persistent neurocognitive symptoms.



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