Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 2014  |  Volume : 56  |  Issue : 4  |  Page : 399-401

Late-onset schizophrenia with isolated cavum vergae: Case report and literature review

1 Department of Psychiatry, Government Medical College, Aurangabad, Maharashtra, India
2 Government Medical College, Aurangabad, Maharashtra, India
3 Paras MRI Centre, Aurangabad, Maharashtra, India
4 Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Correspondence Address:
Chittaranjan Andrade
Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru 560 029, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5545.146533

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Cavum septum pellucidum (CSP) and cavum vergae (CV) have separately and together been associated with an increased risk of neurodevelopmental disorders and psychosis; however, there is little literature on the psychopathological significance of isolated CV, and no previous report of isolated CV in late-onset psychosis. We describe an 80-year-old woman who presented with a 1-month history of psychotic symptoms qualifying for a diagnosis of schizophreniform disorder. Physical (including neurological) examination, bedside cognitive testing, and laboratory investigations were all within normal limits. A magnetic resonance imaging scan of the brain revealed an insignificant CSP with prominent CV. The patient showed almost complete recovery from psychosis after 4-6 weeks of treatment with quetiapine (200 mg/day). She maintained improvement with this medication at an 18-month follow-up; medication taper was associated with re-emergence of hallucinations. We briefly discuss CSP and CV in the context of vulnerability to psychosis. We examine whether isolated CV is a benign and incidental finding versus a biological risk factor for neuropsychiatric illness. We suggest specific studies to resolve the uncertainty.



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