Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 2011  |  Volume : 53  |  Issue : 2  |  Page : 170-171

Severe neuropsychiatric presentation of Wilson's disease

Department of Neurology, T. N. M. C. and B. Y. L. Nair Charitable Hospital, Mumbai Central, Mumbai, Maharashtra, India

Correspondence Address:
Rahul T Chakor
Department of Neurology, T. N. Medical College and B. Y. L. Nair Ch. Hospital, Dr. A. L. Nair Road, Mumbai Central, Mumbai - 400 008, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5545.82556

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Wilson's disease (WD) is a relatively rare disease of copper metabolism. The diagnosis is often missed initially. The presentation is usually neurologic or hepatic, seen in 40% of patients. Psychiatric presentation of WD is reported in only 15% of patients. We present a 32-year-old patient with severe psychiatric manifestations. On examination, he had mild rest and postural tremors and a KF ring was seen. Serum ceruloplasmin was low and 24-hour urinary copper was elevated. The patient responded to penicillamine, lorazepam and quetiapine, and is being followed up.



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