|Year : 2008 | Volume
| Issue : 1 | Page : 51-53
Antidepressant-like activity of tramadol in mice
Bhupinder Singh Kalra, Vandana Tayal, Shalini Chawla
Department of Pharmacology, Maulana Azad Medical College, New Delhi, India
Objective: To evaluate antidepressant-like effect of tramadol in mice.
Materials and Methods: Tramadol was administered at three different doses (10, 20, and 40 mg/kg, i.p.) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug-treated mice was recorded in forced swim test (FST). The antidepressant effect of tramadol was compared to that of fluoxetine (20 mg/kg, i.p.), administered for seven successive days.
Results: Tramadol produced significant antidepressant effect at all the three (10, 20, and 40 mg/kg) doses, as indicated by reduction in immobility times of drug-treated mice compared to control mice. The efficacy of tramadol at doses of 10 and 20 mg/kg was comparable to that of fluoxetine, but antidepressant activity in animals administered with tramadol 40 mg/kg was significantly less as compared to fluoxetine-pretreated mice.
Conclusion: The results of the present study indicate antidepressant-like activity of tramadol.
Bhupinder Singh Kalra
Department of Pharmacology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi - 110 002
Source of Support: None, Conflict of Interest: None
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