|ORIGINAL RESEARCH PAPERS
|Year : 2005 | Volume
| Issue : 2 | Page : 84-88
Comparison of the efficacy and safety of moclobemide and imipramine in the treatment of depression in Indian patients
Ajit Avasthi1, Parmanand Kulhara1, Gagandeep Singh2, Rajni Sharma1, Rajinder P Kaur1
1 Department of Psychiatry, Postgraduate Institute of Medical Education and Research Chandigarh, India
2 Department of Psychiatry Government Medical College and Hospital, Chandigarh, India
Background: Moclobemide, a benzamide, is one of the new-generation monoamine oxidase-A inhibitors (MAO-AIs) which belongs to the class of reversible inhibitors of monoamine oxidase (RIMA). Numerous studies have shown that moclobemide is well-tolerated and as effective as other antidepressants. So far, there is no evidence available regarding its efficacy and tolerability in India.
Aim: To compare the efficacy and safety of moclobemide with that of imipramine, a tricyclic antidepressant, in the treatment of major depressive disorder.
Methods: In this prospective study, patients (n=60) were randomly assigned to treatment with moclobemide or imipramine for 6 weeks. Efficacy of the drugs was assessed by observing the mean change in scores on the Hamilton Depression Rating Scale (HDRS) and the Montgomery-Asberg Depression Scale (MADRS).
Results: Both the groups showed significant decrease in scores at the end of 6 weeks. Patients who received moclobemide had a better side-effect profile.
Conclusion: Moclobemide is an effective antidepressant and is better tolerated than imipramine.
Department of Psychiatry, Postgraduate Institute of Medical Education and Research Chandigarh 160012
Source of Support: None, Conflict of Interest: None
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