| ORIGINAL ARTICLE |
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| Year : 2003 | Volume
: 45
| Issue : 3 | Page : 145-150 |
Enlargement of the Third Ventricle in affective Disorders
Rano Bhadoria, David Watson, Paul Danson, Ian Nicol Ferrier, Victor I Mcallister, Peter Brian Moore
Senior Lecturer. Department of Psychiatry, Royal Victoria Infirmary, Consultant Neuroradiologist, Newcastle General Hospital, Newcastle upon tyne NE4, United Kingdom
Correspondence Address:
Rano Bhadoria
Senior Lecturer. Department of Psychiatry, Royal Victoria Infirmary, Consultant Neuroradiologist, Newcastle General Hospital, Newcastle upon tyne NE4, United Kingdom
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 21206844 
Introduction : There have been inconsistent reports of dilation of the third ventricle (lll-V) in bipolar disorder. Within the lateral walls of lll-V are hypothalamic nuclei which mediate the neuroendocrine, sleep, appetite and autonomic disturbances which characterise a depressive episode.
Methods : The lll-V width, immediately anterior to the mamillary bodies, was measured in 74 bipolar I or II subjects (m=25, f=49, mean age 36.1(1 l.3yr) and 33 healthy controls (m= 17, f= 16, mean age 35.6( 12.6yr) from MRI coronal inversion recovery scans.
Results : Bipolar subjects had significantly (t=2.l6,p=0.03) wider lll-V (0.45(0.15cm) than controls (0.40(0.12cm). Examining data with a General Linear Model with gender and diagnoses as categoric variables and age as a continuous variable, lll-V width depended significantly on gender (p=O.OI6), age (p<0.00l) and differed significantly (p=0.03) between bipolar subjects and controls. The rate of lll-V dilation was estimated to be 0.0048cm/yr in male bipolar subjects and 0.0040cm/yr in females.
Comment : Bipolar disorder is associated with increased lll-V width and progressive dilation. It is proposed that dilation may be associated with dysfunction of hypothalamic nuclei in the lll-V lateral walls.
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