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Year : 2000  |  Volume : 42  |  Issue : 3  |  Page : 308-311

Effects of Zopicloone and Lorazepam on ECT Seizure Duration : Clinical Implications of Findings from an Animal Model

1 Additional Professor & Head, Department of Psychopharmacology, NIMHANS, Bangalore-560 029, India
2 Project Officer, Department of Psychopharmacology, NIMHANS, Bangalore-560 029, India
3 Research Associate, Department of Pharmacology, St. John's Medical College, Bangalore-560 034, India
4 Central Animal Research Facility, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India

Correspondence Address:
Chittaranjan Andrade
Additional Professor & Head, Department of Psychopharmacology, NIMHANS, Bangalore-560 029
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Source of Support: None, Conflict of Interest: None

PMID: 21407962

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Lorazepam is commonly prescribed to treat insomnia in depressed patients who receive electroconvulsive therapy (ECT); however, lorazepam may interfere with ECT seizure parameters, and may thereby compromise the efficacy of the treatment. This study therefore sought to assess whether zopicione, a hypnotic agent, interferes less with the ECT seizure. For ethical reasons, the study utilized an animal model. Sprague-Dawley rats (n=10/group) received either zopicione (1.5 mg/ kg), lorazepam (0.2 mg/kg), or a placebo equivalent. After 30 minutes, an electroconvulsive shock was administered to the rats. It was observed that the motor seizure duration but not the total motoric phase was significantly attenuated by zopicione. Lorazepam did not impact significantly upon either seizure measure. It is concluded that zopicione may be a suitable hypnotic for patients receiving ECT only if sufficient time is allowed for the drug to be substantially washed out of the body.



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