Indian Journal of PsychiatryIndian Journal of Psychiatry
Home | About us | Current Issue | Archives | Ahead of Print | Submission | Instructions | Subscribe | Advertise | Contact | Login 
    Users online: 1281 Small font sizeDefault font sizeIncrease font size Print this article Email this article Bookmark this page
Search Again
 Table of Contents
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Article Access Statistics
 Reader Comments
 Email Alert
 Add to My List
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded302    
    Comments [Add]    

Recommend this journal

Year : 2000  |  Volume : 42  |  Issue : 3  |  Page : 243-246

A Study of Thyroid Hormones (T 3 , T 4 & TSH) in Patients of Depression

1 Lecturer (Physiology), J.N. Medical College, AMU, Aligarh, India
2 Professor (Physiology), J.N. Medical College, AMU, Aligarh, India
3 Professor (Phychiatry), J.N. Medical College, AMU, Aligarh, India

Correspondence Address:
Jalaj Saxena
Shambhu Niwas, Pandav Bagh, Railway Road, Farrukhabad-209 625
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 21407950

Rights and PermissionsRights and Permissions

In this study, 32 unmedicated patients of unipolar depression were included and blood samples were analysed for T 3 , T 4 and TSH. These were compared with age and sex matched controls. Subnormal T 3 and T 4 levels in 90.6% and 9.3% respectively and an increase of TSH levels in 18.7% of the total patients was observed in this study. The patients were classified into mild, moderate and severe grade of depression as per DSM-IV criteria. Of the mild 66.6%, 93.3% of moderate and all of the severe grade depression patients had low T 3 levels. Of the moderately depressed patients 13.3% and 9.0% of severe depression patients had low T 4 levels. TSH was increased than normal in 54.5% of the patients and all these patients were of severe grade. ANOVA with multiple comparison testing shows significant decrease in levels of T 3 (F 229 >3.33) and significant increase in TSH levels (F 229 >3.33) at 5% level of significance amongst mild, moderate and severe grade of depression patients. This study suggests a subclinical hypothyroidism in most of the patients which could lead to nonresponsiveness to the conventional antidepressant therapy. Therefore, evaluation of thyroid status prior to antidepressant therapy and subsequent thyroid hormone substitution in subclinical hypothyroid patients is suggested.



Print this article         Email this article