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| Year : 1999 | Volume
: 41
| Issue : 4 | Page : 377-380 |
Primary Hypersomnia : Response to Fluoxetine and Methylphenidate
Chittaranjan Andrade
Additional Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India
Correspondence Address:
Chittaranjan Andrade
Additional Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 21430816 
Primary hypersomnia, a rare clinical syndrome, was diagnosed in a 14-year-old boy. The syndrome showed partial response to high dose fluoxetine therapy (120 mg/day) which recruited insomnia, an adverse effect of the drug, for therapeutic purposes. Response was enhanced with intermittent methylphenidate in association with a lower dose of fluoxetine. A possible pharmacokinetic interaction developed, comprising fluoxetine-induced augmentation of methylphenidate activity; such an interaction has not been previously reported.
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