Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 1999  |  Volume : 41  |  Issue : 4  |  Page : 358-363

Which Antidepressants are Best Tolerated in Primary Care ? A Pilot Randomized Trial From Goa

1 Registrar, The Maudsley Hospital, London, UK; and Research Officer, Institute of Psychiatry & Human Behaviour, Panaji, Goa, India
2 Senior Lecturer, Section of Epidemiology & General Practice, Instidute of Psychiatry, London, UK; and MacArthur Population Fellow, Sangath Society, Goa, India

Correspondence Address:
Jerson Pereira
Sangath Centre, 48, Defence Colony, Alto Porvorim, Goa-403 521

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Source of Support: None, Conflict of Interest: None

PMID: 21430811

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Even though cultural, biological and health service factors influence the tolerance and acceptability of psychotropic drugs in different settings, there is a lack of data on the use of antidepressants in primary care settings from India. The aim of this study was to examine the tolerance of 3 models of antidepressants treatments (fluoxetine 20 mg; imipramine 75 mg; imipramine 150 mg) for common mental disorders in attenders at a primary care clinic in Goa. The study design was a randomized trial. A total of€1 adult subjects with a common mental disorder were recruited and randomized to one of the 3 groups. Subjects were reviewed at 2 and 6 weeks. The main outcome measures were discontinuation rates. The key findings are that while discontinuation rates are higher in subjects on imipramine 150 mg as compared to the other groups, the majority of subjects in all groups discontinued their medication. The commonest reasons for discontinuation are anticholingeric and hypotensive side effects.



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