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| Year : 1997 | Volume
: 39
| Issue : 4 | Page : 272-277 |
ECT and Platelet 5 HT Uptake in Major Depression
PK Dalal1, Narottam Lal2, JK Trivedi2, PK Seth3, AK Agarwal4, Abdul Khalid5
1 Associate Professor, Department of Psychiatry, K.G'S Medical College, Lucknow-226003, India
2 Professor, Department of Psychiatry, K.G'S Medical College, Lucknow-226003, India
3 Director, Department of Psychiatry, K.G'S Medical College, Lucknow-226003, India
4 Scientist, Department of Psychiatry, K.G'S Medical College, Lucknow-226003, India
5 Senior Resident, Department of Psychiatry, K.G'S Medical College, Lucknow-226003, India
Correspondence Address:
P K Dalal
Associate Professor, Department of Psychiatry, K.G'S Medical College, Lucknow-226003
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 21584091 
Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The mechanism of antidepressant action of ECT is not clear. The present work was undertaken with the aim to study the active platelet 5-HT uptake and the effect of ECT on it in patients of major depression. 15 patients of major depression (DSM-lll-R) and equal number of age and sex-matched controls were included in the study. Active platelet 5-HT uptake was determined before ECT, after a course of ECT and 7 days after last ECT. Platelet 5-HT uptake was. significantly lower in der essives than normal controls. After ECT treatment there was significant increase in 5-HT uptake which came down to pretreatment level after 1 week of last ECT. The effect of ECT on serotonergic system is discussed.
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